Remote control of bioreactions in multicompartment capsules

Oliver Kreft, Andre G. Skirtach, Gleb B. Sukhorukov, Helmuth Möhwald

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)

Abstract

A study was conducted to demonstrate the feasibility of conducting bioreactions in multicompartment capsules, with a model system based on two-compartment polyelectrolyte capsules. The polyelectrolyte capsules were designed, with the outer compartment built concentrically around the inner compartment. Light absorbing gold nanoparticles were incorporated into the inner compartment, while intermixing of the contents of the two compartments occurred, when near-infrared laser light illuminated the capsules, disrupting the inner capsule. The contents of the inner capsule were released into the outer capsule, providing a route for reactions in confined volumes and intermixing of the contents of the two compartments. Researchers used capsules whose inner compartment was filled with a high molecular weight TRITC-labelled dextran, while outer compartment was loaded with a FITC-labelled dextran species to conduct the study.

Original languageEnglish
Pages (from-to)3142-3145
Number of pages4
JournalAdvanced Materials
Volume19
Issue number20
DOIs
Publication statusPublished - 19 Oct 2007
Externally publishedYes

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