Relationship between the Size of Magnetic Nanoparticles and Efficiency of MRT Imaging of Cerebral Glioma in Rats

A. S. Semkina, M. A. Abakumov, A. M. Abakumov, N. V. Nukolova, V. P. Chekhonin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

BSA-coated Fe3O4 nanoparticles with different hydrodynamic diameters (36±4 and 85±10 nm) were synthesized, zeta potential and T2 relaxivity were determined, and their morphology was studied by transmission electron microscopy. Studies on rats with experimental glioma C6 showed that smaller nanoparticles more effectively accumulated in the tumor and circulated longer in brain vessels. Optimization of the hydrodynamic diameter improves the efficiency of MRT contrast agent.

Original languageEnglish
Pages (from-to)292-295
Number of pages4
JournalBulletin of Experimental Biology and Medicine
Volume161
Issue number2
DOIs
Publication statusPublished - 1 Jun 2016
Externally publishedYes

Keywords

  • cerebral glioma
  • magnetic nanoparticles
  • MRT diagnosis

Fingerprint

Dive into the research topics of 'Relationship between the Size of Magnetic Nanoparticles and Efficiency of MRT Imaging of Cerebral Glioma in Rats'. Together they form a unique fingerprint.

Cite this