Regulatory T cells prevent liver fibrosis during HIV type 1 infection in a humanized mouse model

Jun Ichi Nunoya, Michael L. Washburn, Grigoriy I. Kovalev, Lishan Su

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) disease is associated with aberrant immune activation, and coinfection with hepatitis C virus (HCV) exacerbates hepatic inflammation and fibrosis. However, the role of HIV-1 infection or host immune modulation in liver pathogenesis is not clearly defined. Here, we report that regulatory T (Treg) cells prevent liver immunopathogenesis during HIV-1 infection in a humanized mouse model. In the absence of Treg cells, HIV-1 infection induced liver fibrosis associated with hepatic stellate cell activation, hepatitis, and liver injury. Our findings provide new insight linking Treg cells and liver immunopathogenesis during HIV-1 infection.

Original languageEnglish
Pages (from-to)1039-1044
Number of pages6
JournalJournal of Infectious Diseases
Volume209
Issue number7
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • HIV-1 infection
  • inflammation
  • liver fibrosis
  • Treg cells

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