Regulation of nitrogen metabolism in gram-positive bacteria

N. A. Doroshchuk, M. S. Gelfand, D. A. Rodionov

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


A search for new members of the TnrA and GlnR regulons, responsible for assimilation of nitrogen in Gram-positive bacteria, was performed. Common regulatory signals with consensus sequences ATGTNAWWWWWWWTNACAT and TGTNAWWWWWWWTNACA were identified for GlnR and TnrA, respectively. The structure was described and new potential members were found in Bacillus subtilis, B. licheniformis, Geobacillus kaustophilus, and Oceanobacillus iheyensis for the TnrA/GlnR regulons; in B. halodurans for the TnrA regulon; and in Lactococcus lactis, Lactobacillus plantarum, Streptococcus pyogenes, S. pneumoniae, S. mutans, S. agalactiae, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, and St. epidermidis for the GlnR regulon.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
JournalMolecular Biology
Issue number5
Publication statusPublished - Oct 2006
Externally publishedYes


  • Assimilation of nitrogen
  • Bacillus subtilis
  • GlnR regulon
  • TnrA regulon


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