Regulation of gene expression in type II restriction-modification system

M. O. Nagornykh, E. S. Bogdanova, A. S. Protsenko, M. V. Zakharova, A. S. Solonin, K. V. Severinov

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


Type II restriction-modification systems are comprised of a restriction endonuclease and methyltransferase. The enzymes are coded by individual genes and recognize the same DNA sequence. Endonuclease makes a double-stranded break in the recognition site, and methyltransferase covalently modifies the DNA bases within the recognition site, thereby down-regulating endonuclease activity. Coordinated action of these enzymes plays a role of primitive immune system and protects bacterial host cell from the invasion of foreign (for example, viral) DNA. However, uncontrolled expression of the restriction-modification system genes can result in the death of bacterial host cell because of the endonuclease cleavage of host DNA. In the present review, the data on the expression regulation of the type II restriction-modification enzymes are discussed.

Original languageEnglish
Pages (from-to)606-615
Number of pages10
Issue number5
Publication statusPublished - May 2008
Externally publishedYes


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