Regulation of bacterial respiration: Comparison of microarray and comparative genomics data

M. O. Tsiganova, M. S. Gelfand, D. A. Ravcheev

Research output: Contribution to journalArticlepeer-review

Abstract

A comparison was made of the structures of the Fnr and ArcA modulons and regulons. The data on modulon composition were taken from published microarray assays, whereas regulons were characterized using comparative genomic approaches. The regulatory cascade involving Fnr and ArcA contributes greatly to the extension of the Fnr modulon over the Fnr regulon by adding operons of the ArcA modulon. The Fnr and ArcA regulons were shown to contain 26 and 16 operons, respectively. Ten operons had high-score and highly conserved sites for both Fnr and ArcA and were isolated as a so-called core of regulons.

Original languageEnglish
Pages (from-to)497-512
Number of pages16
JournalMolecular Biology
Volume41
Issue number3
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Keywords

  • Aerobic and anaerobic respiration
  • ArcA
  • Comparative genomics
  • Enterobacteriales
  • Fnr
  • Modulon
  • Regulon

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