Reconstruction of the chromatin 3D conformation from single cell Hi-C data

Pavel I. Kos, Aleksandra A. Galitsyna, Sergey V. Ulianov, Mikhail S. Gelfand, Sergey V. Razin, Alexander V. Chertovich

    Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

    Abstract

    In the last decade, experimental methods for determining the spatial organization of chromatin have been actively developed. One of the known classes of such methods is 3C-based methods. Hi-C experiments, which are a full-genome variation of 3C-based methods, allow obtaining contact maps for a population of 10 million cells with an accuracy of 500 base pairs. In parallel with the improvement of experiments, theoretical models were created to describe the spatial organization of chromatin. These models include: crumpled (fractal) globule, SBS model, loop extrusion model and others. All this models describe chromatin conformation well on different spatial scales. Another task is the chromatin conformation recovery from the experimental Hi-C contact map obtained for the cell population. This task is incorrectly set because it has many solutions. In addition, the individual features of the spatial organization of chromatin in individual cells are not visible due to averaging.

    Original languageEnglish
    Title of host publicationProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
    EditorsHarald Schmidt, David Griol, Haiying Wang, Jan Baumbach, Huiru Zheng, Zoraida Callejas, Xiaohua Hu, Julie Dickerson, Le Zhang
    PublisherInstitute of Electrical and Electronics Engineers Inc.
    Number of pages1
    ISBN (Electronic)9781538654880
    DOIs
    Publication statusPublished - 21 Jan 2019
    Event2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018 - Madrid, Spain
    Duration: 3 Dec 20186 Dec 2018

    Publication series

    NameProceedings - 2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018

    Conference

    Conference2018 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2018
    Country/TerritorySpain
    CityMadrid
    Period3/12/186/12/18

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