Recognition of regulatory sites by genomic comparison

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Availability of complete bacterial genomes opens the way to the comparative approach to the recognition of transcription regulatory sites. Assumption of regulon conservation in conjunction with profile analysis provides two lines of independent evidence making it possible to make highly specific predictions. Recently this approach was used to analyze several regulons in eubacteria and archaebacteria. The present review covers recent advances in the comparative analysis of transcriptional regulation in prokaryotes and phylogenetic fingerprinting techniques in eukaryotes, and describes the emerging patterns of the evolution of regulatory systems.

Original languageEnglish
Pages (from-to)755-771
Number of pages17
JournalResearch in Microbiology
Issue number9-10
Publication statusPublished - Nov 1999
Externally publishedYes


  • Activator
  • Complete genome
  • Computer analysis
  • Operator
  • Regulation
  • Repressor
  • Transcription


Dive into the research topics of 'Recognition of regulatory sites by genomic comparison'. Together they form a unique fingerprint.

Cite this