Recent advancements in matrix-assisted laser desorption/ionization mass spectrometry imaging

Teesha C. Baker, Jun Han, Christoph H. Borchers

Research output: Contribution to journalReview articlepeer-review

82 Citations (Scopus)

Abstract

Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a robust tool for spatially resolved analysis of biomolecules in situ. Recent advances in high ionization-efficiency MALDI matrices, new matrix deposition procedures, and the development of high spatial-resolution and high sensitivity MS instruments continue to drive new applications of MALDI-MSI, along with other MSI techniques, which allow us to visualize and determine the regio-specific and temporal changes in proteins, peptides, lipids, drug molecules, and metabolites within the tissues, cells and microorganisms. These provide researchers with a new route to the discovery of potential biomarkers of human disease and elucidation of the underlying biology of metabolic regulation, thus bringing our understanding of human health to a new level.

Original languageEnglish
Pages (from-to)62-69
Number of pages8
JournalCurrent Opinion in Biotechnology
Volume43
DOIs
Publication statusPublished - 1 Feb 2017
Externally publishedYes

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