Quantitative ESI-MS analysis of antiarrhythmic drugs in blood plasma without chromatographic separation

Y. O. Karatasso, I. V. Logunova, M. G. Sergeeva, E. N. Nikolaev, S. D. Varfolomeev, V. V. Chistyakov

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A highly sensitive method for the quantitative determination of a potential antiarrhythmic drug (OF-7976) in the blood plasma has been developed. The method is based on the electron spray ionization/mass spectrometry (ESI-MS) technique without preliminary chromatographic separation and makes use of nibentan as the internal standard. A linear relationship between drug concentration and the peak intensity of ions of the analyzed substance (m/z = 398) and the internal standard (m/z = 382) is established. The detection limit is 3 ng/(0.5 ml plasma). The method is linear from 3 to 25 ng/(0.5 ml plasma) with a correlation coefficient of 0.98. The coefficient of variation was less than 7 %.

Original languageEnglish
Pages (from-to)166-169
Number of pages4
JournalPharmaceutical Chemistry Journal
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

Fingerprint

Dive into the research topics of 'Quantitative ESI-MS analysis of antiarrhythmic drugs in blood plasma without chromatographic separation'. Together they form a unique fingerprint.

Cite this