[Profile of sex steroids in healthy volunteers' urine during experiment in isolated object].

I. M. Larina, E. A. Kochnova, L. K. Pastushkova, G. M. Rodchenkov, A. M. Nosovskiǐ, E. N. Nikolaev

Research output: Contribution to journalArticlepeer-review

Abstract

The quantitative determination a number of endogenous steroids and their metabolites in urine of healthy volunteers by means of gas chromatography - mass spectrometry was performed. The dynamic of steroid profile of healthy individuals as well as possible ranges of several endogenous steroid parameters have been investigated. Samples were obtained during 105-days experiment with 6 volunteers in isolated on ground modules where were modeling the main life conditions which could influence the steroid profile: meal volume and composition, water consumption, motion activity, air composition and temperature, rate sleep - wakefulness and emotional tension. The parameters of urine steroid profile of healthy volunteer which were affected by life conditions in isolated object were revealed. The parameters of individual and group variability of steroid profile and its dependence from definite experiment conditions - change of salt consumption periods, autonomy of vital activity were detected.

Original languageEnglish
Pages (from-to)79-89
Number of pages11
JournalFiziologiia cheloveka
Volume37
Issue number4
Publication statusPublished - Jul 2011
Externally publishedYes

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