Principles of neural ensemble physiology underlying the operation of brain-machine interfaces

Miguel A.L. Nicolelis, Mikhail A. Lebedev

Research output: Contribution to journalReview articlepeer-review

312 Citations (Scopus)

Abstract

Research on brain-machine interfaces has been ongoing for at least a decade. During this period, simultaneous recordings of the extracellular electrical activity of hundreds of individual neurons have been used for direct, real-time control of various artificial devices. Brain-machine interfaces have also added greatly to our knowledge of the fundamental physiological principles governing the operation of large neural ensembles. Further understanding of these principles is likely to have a key role in the future development of neuroprosthetics for restoring mobility in severely paralysed patients.

Original languageEnglish
Pages (from-to)530-540
Number of pages11
JournalNature Reviews Neuroscience
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2009
Externally publishedYes

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