Preparation of 2′-hydrazino oligonucleotides and their reaction with aldehydes and 1,3-diketones

Timofei S. Zatsepin, Tatiana S. Oretskaya, Michael J. Gait, Dmitry A. Stetsenko

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Oligodeoxyribonucleotides that contain a hydrazino nucleoside, 2′-O-(2-hydrazinoethyl)uridine were prepared and shown to react with aldehydes or 1,3-diketones with the formation of hydrazones or pyrazoles, respectively. The method may be applicable for the preparation of oligonucleotide-peptide conjugates.

Original languageEnglish
Pages (from-to)795-798
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number6-7
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Keywords

  • 1,3-diketone
  • Aldehyde
  • Conjugation
  • Hydrazone
  • Oligonucleotide
  • Pyrazole

Fingerprint

Dive into the research topics of 'Preparation of 2′-hydrazino oligonucleotides and their reaction with aldehydes and 1,3-diketones'. Together they form a unique fingerprint.

Cite this