Direct simulations of laminar solid-liquid flow in microchannels with full resolution of the solid-liquid interfaces have been performed. The solids phase consists of simple agglomerates, assembled of monosized, spherical particles. The flow of the interstitial liquid is solved with the lattice-Boltzmann method. Solids and fluid dynamics are two-way coupled. The simulations keep track of the flow-induced forces in the agglomerates. The effects of agglomerate type (doublets, triplets, and quadruplets), solids loading, and channel geometry on (the statistics of the) flow and collision-induced forces has been investigated. By comparing these forces with agglomerate strength, we would be able to assess the potential of microchannels as agglomerate breakage devices.