Potassium Salt of Fullerenylpenta-N-Dihydroxytyrosine Effects on Type 2 Diabetes Mellitus Therapeutic Targets

Yu V. Soldatova, R. A. Kotelnikova, A. V. Zhilenkov, I. I. Faingold, P. A. Troshin, M. A. Kozlova, D. A. Areshidze, S. M. Aldoshin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Abstract: It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) affects three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also has an antiglycation effect on bovine serum albumin. The inhibition constants for these enzymes were calculated.

Original languageEnglish
Pages (from-to)320-323
Number of pages4
JournalDoklady Biochemistry and Biophysics
Volume488
Issue number1
DOIs
Publication statusPublished - 1 Sep 2019

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