Polymorphism due to multiple amino acid substitutions at a codon site within Ciona savignyi

Nilgun Donmez, Georgii A. Bazykin, Michael Brudno, Alexey S. Kondrashov

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We compared two haploid genotypes of one Ciona savignyi individual and identified codons at which these genotypes differ by two nonsynonymous substitutions. Using the C. intestinalis genome as an outgroup, we showed that both substitutions tend to occur in the same genotype. Only in 53 (34.4%) of 154 codons, one substitution occurred in each of the two genotypes, although 77 (50%) of such codons are to be expected if substitutions were independent. We considered two feasible evolutionary causes for the observed pattern: substitutions driven by positive selection and compensatory substitutions, as well as several potential biases. However, none of these explanations is fully compelling, and data on multiple genotypes of C. savignyi would help to elucidate the causes of this pattern.

Original languageEnglish
Pages (from-to)685-690
Number of pages6
JournalGenetics
Volume181
Issue number2
DOIs
Publication statusPublished - Feb 2009
Externally publishedYes

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