Polyelectrolyte Parg/DS submicrocapsules functionalized by magnetite nanoparticles as effective MR contrast agents

A. A. Kozlova, S. V. German, M. V. Novoselova, P. A. Demina, V. S. Atkin, V. V. Zuev, D. A. Gorin

    Research output: Contribution to journalConference articlepeer-review

    3 Citations (Scopus)

    Abstract

    Polyelectrolyte microcapsules functionalized by Fe3O4 nanoparticles have proved to be perspective magnetic resonance (MR) contrast agents. Here we report about submicron-sized capsules with a shell made of poly-L-arginine and dextran sulfate. Such polymers are biodegradable, thus they are suitable to use as components of drug delivery carriers. To functionalize submicrocapsules by magnetite freezing and layer-by-layer method were used. MR study of obtained samples was carried out, and signal intensity change dependencies on submicrocapsules concentration by mass amount of iron oxide (III) nanoparticles were shown. The sample with optimal MR contrast characteristics was found as well, and an ability to use it as a bimodal MR agent was demonstrated.

    Original languageEnglish
    Article number012067
    JournalJournal of Physics: Conference Series
    Volume1092
    DOIs
    Publication statusPublished - 2018
    Event3rd International Conference on Metamaterials and Nanophotonics, METANANO 2018 - Sochi, Russian Federation
    Duration: 17 Sep 201821 Sep 2018

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