Polycaprolactone-Based, Porous CaCO3 and Ag Nanoparticle Modified Scaffolds as a SERS Platform With Molecule-Specific Adsorption

Mariia Saveleva, Ekaterina Prikhozhdenko, Dmitry Gorin, Andre G. Skirtach, Alexey Yashchenok, Bogdan Parakhonskiy

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Surface-enhanced Raman scattering (SERS) is a high-performance technique allowing detection of extremely low concentrations of analytes. For such applications, fibrous polymeric matrices decorated with plasmonic metal nanostructures can be used as flexible SERS substrates for analysis of analytes in many application. In this study, a three-dimensional SERS substrate consisting of a CaCO3-mineralized electrospun (ES) polycaprolactone (PCL) fibrous matrix decorated with silver (Ag) nanoparticles is developed. Such modification of the fibrous substrate allows achieving a significant increase of the SERS signal amplification. Functionalization of fibers by porous CaCO3 (vaterite) and Ag nanoparticles provides an effective approach of selective adsorption of biomolecules and their precise detection by SERS. This new SERS substrate represents a promising biosensor platform with selectivity to low and high molecular weight molecules.

    Original languageEnglish
    Article number888
    JournalFrontiers in Chemistry
    Volume7
    DOIs
    Publication statusPublished - 10 Jan 2020

    Keywords

    • calcium carbonate
    • Raman
    • SERS
    • silver nanoparticles
    • vaterite

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