Photodynamic opening of the blood-brain barrier and pathways of brain clearing

Oxana Semyachkina-Glushkovskaya, Vladimir Chehonin, Ekaterina Borisova, Ivan Fedosov, Anton Namykin, Arkady Abdurashitov, Alexander Shirokov, Boris Khlebtsov, Yelena Lyubun, Nikita Navolokin, Mariya Ulanova, Natalia Shushunova, Alexander Khorovodov, Ilana Agranovich, Anastasia Bodrova, Madina Sagatova, Ali Esmat Shareef, Elena Saranceva, Tatyana Iskra, Mariya DvoryatkinaEkaterina Zhinchenko, Olga Sindeeva, Valery Tuchin, Jurgen Kurths

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate 2 pathways for the brain clearing: (1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal lymphatic system in the subdural space; (2) using optical coherence tomography and intraparenchymal injection of gold nanorods, we observed their clearance through the exit gate of cerebral spinal fluid from the brain into the deep cervical lymph node, where the gold nanorods were accumulated. These data contribute to a better understanding of the cerebrovascular effects of PDT and shed light on mechanisms, underlying brain clearing after PDT-related opening of BBB, including clearance from nanoparticles as drug carriers.

Original languageEnglish
Article numbere201700287
JournalJournal of Biophotonics
Volume11
Issue number8
DOIs
Publication statusPublished - Aug 2018
Externally publishedYes

Keywords

  • blood-brain barrier
  • cerebral lymphatic vessels
  • gold nanorods
  • optical coherence tomography
  • photodynamic treatment

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