Peptide biomarkers used for the selective breeding of a complex polygenic trait in honey bees

M. Marta Guarna, Shelley E. Hoover, Elizabeth Huxter, Heather Higo, Kyung Mee Moon, Dominik Domanski, Miriam E.F. Bixby, Andony P. Melathopoulos, Abdullah Ibrahim, Michael Peirson, Suresh Desai, Derek Micholson, Rick White, Christoph H. Borchers, Robert W. Currie, Stephen F. Pernal, Leonard J. Foster

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

We present a novel way to select for highly polygenic traits. For millennia, humans have used observable phenotypes to selectively breed stronger or more productive livestock and crops. Selection on genotype, using single-nucleotide polymorphisms (SNPs) and genome profiling, is also now applied broadly in livestock breeding programs; however, selection on protein/peptide or mRNA expression markers has not yet been proven useful. Here we demonstrate the utility of protein markers to select for disease-resistant hygienic behavior in the European honey bee (Apis mellifera L.). Robust, mechanistically-linked protein expression markers, by integrating cis- A nd trans- effects from many genomic loci, may overcome limitations of genomic markers to allow for selection. After three generations of selection, the resulting marker-selected stock outperformed an unselected benchmark stock in terms of hygienic behavior, and had improved survival when challenged with a bacterial disease or a parasitic mite, similar to bees selected using a phenotype-based assessment for this trait. This is the first demonstration of the efficacy of protein markers for industrial selective breeding in any agricultural species, plant or animal.

Original languageEnglish
Article number8381
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

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