Peculiarities of data interpretation upon direct tissue analysis by Fourier transform ion cyclotron resonance mass spectrometry

Vitaliy Chagovets, Aleksey Kononikhin, Nataliia Starodubtseva, Yury Kostyukevich, Igor Popov, Vladimir Frankevich, Eugene Nikolaev

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    The importance of high-resolution mass spectrometry for the correct data interpretation of a direct tissue analysis is demonstrated with an example of its clinical application for an endometriosis study. Multivariate analysis of the data discovers lipid species differentially expressed in different tissues under investigation. High-resolution mass spectrometry allows unambiguous separation of peaks with close masses that correspond to proton and sodium adducts of phosphatidylcholines and to phosphatidylcholines differing in double bond number.

    Original languageEnglish
    Pages (from-to)123-126
    Number of pages4
    JournalEuropean Journal of Mass Spectrometry
    Volume22
    Issue number3
    DOIs
    Publication statusPublished - 19 Aug 2016

    Keywords

    • Ambient mass spectrometry
    • Direct tissue analysis
    • Endometriosis
    • Fourier transform ion cyclotron resonance
    • Mass spectrometry clinical application

    Fingerprint

    Dive into the research topics of 'Peculiarities of data interpretation upon direct tissue analysis by Fourier transform ion cyclotron resonance mass spectrometry'. Together they form a unique fingerprint.

    Cite this