Optogenetic experimentation on astrocytes

M. Figueiredo, S. Lane, F. Tang, B. H. Liu, J. Hewinson, N. Marina, V. Kasymov, E. A. Souslova, D. M. Chudakov, A. V. Gourine, A. G. Teschemacher, S. Kasparov

Research output: Contribution to journalReview articlepeer-review

66 Citations (SciVal)

Abstract

We briefly review the current literature where optogenetics has been used to study various aspects of astrocyte physiology in vitro and in vivo. This includes both genetically engineered Ca2+ sensors and effector proteins, such as channelrhodopsin. We demonstrate how the ability to target astrocytes with cell-specific viral vectors to express optogenetic constructs helped to unravel some previously unsuspected roles of these inconspicuous cells.

Original languageEnglish
Pages (from-to)40-50
Number of pages11
JournalExperimental Physiology
Volume96
Issue number1
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

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