Optoacoustic visualization of individual core-shell microparticles in vivo

Daniil Nozdriukhin, Sandeep Kumar Kalva, Weiye Li, Jim Zhao, Alexey Yashchenok, Dmitry Gorin, Daniel Razansky, Xosé Luís Deán-Ben

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The feasibility of real-time tracking of microparticles intravenously injected into living organisms can significantly facilitate the development of new biomedical applications, including blood flow characterization, drug delivery, and many others. However, existing imaging modalities generally lack the sensitivity to detect the weak signals generated by individual particles flowing through vascular networks deep within biological tissues. Also, the temporal resolution is usually insufficient to track the particles in an entire three-dimensional region. Herein, we capitalize on the unique advantages of a state-of-the-art high-frame-rate optoacoustic tomographic imaging system to visualize and track monodisperse core-shell microparticles with a diameter of 4m in the mouse brain vasculature. The feasibility of localizing individual solid particles smaller than red blood cells opens new opportunities for mapping the blood flow velocity, enhancing the resolution and visibility of optoacoustic images, and developing new biosensing assays.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2022
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510647916
DOIs
Publication statusPublished - 2022
EventPhotons Plus Ultrasound: Imaging and Sensing 2022 - Virtual, Online
Duration: 20 Feb 202224 Feb 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11960
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2022
CityVirtual, Online
Period20/02/2224/02/22

Keywords

  • Microparticles
  • Optoacoustic Imaging
  • Photoacoustic Imaging
  • Tracking

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