Optical monitoring of stress-related changes in the brain tissues and vessels associated with hemorrhagic stroke in newborn rats

Oxana Semyachkina-Glushkovskaya, Alexey Pavlov, Jürgen Kurths, Ekaterina Borisova, Alexander Gisbrecht, Olga Sindeeva, Arkady Abdurashitov, Alexander Shirokov, Nikita Navolokin, Ekaterina Zinchenko, Artem Gekalyuk, Maria Ulanova, Dan Zhu, Qingming Luo, Valery Tuchin

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Stress is a major factor for a risk of cerebrovascular catastrophes. Studying of mechanisms underlying stress-related braininjures in neonates is crucial for development of strategy to prevent of neonatal stroke. Here, using a model of sound-stress-induced intracranial hemorrhages in newborn rats and optical methods, we found that cerebral veins are more sensitive to the deleterious effect of stress than arteries and microvessels. The development of venous insufficiency with decreased blood outflow from the brain accompanied by hypoxia, reduction of complexity of venous blood flow and high production of beta-arrestin-1 are possible mechanisms responsible for a risk of neonatal hemorrhagic stroke.

Original languageEnglish
Article numberA013
Pages (from-to)4088-4097
Number of pages10
JournalBiomedical Optics Express
Volume6
Issue number10
DOIs
Publication statusPublished - 1 Oct 2015
Externally publishedYes

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