Optical coherence microangiography of the mouse kidney for diagnosis of circulatory disorders

Arkady S. Abdurashitov, Ekaterina S. Prikhozhdenko, Oksana A. Mayorova, Valentina O. Plastun, Olga I. Gusliakova, Natalia A. Shushunova, Oleg A. Kulikov, Valery V. Tuchin, Gleb B. Sukhorukov, Olga A. Sindeeva

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Optical coherence tomography (OCT) has become widespread in clinical applications in which precise three-dimensional functional imaging of living organs is required. Nevertheless, the kidney is inaccessible for the high resolution OCT imaging due to a high light attenuation coefficient of skin and soft tissues that significantly limits the penetration depth of the probing laser beam. Here, we introduce a surgical protocol and fixation scheme that enables functional visualization of kidney's peritubular capillaries via OCT microangiography. The model of reversible/irreversible glomerulus embolization using drug microcarriers confirms the ability of OCT to detect circulatory disorders. This approach can be used for choosing optimal carriers, their dosages and diagnosis of other blood flow pathologies.

Original languageEnglish
Pages (from-to)4467-4477
Number of pages11
JournalBiomedical Optics Express
Volume12
Issue number7
DOIs
Publication statusPublished - 1 Jul 2021

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