Many factors affect the efficiency of polymer flooding, but the key is polymer adsorption on the rock. Theanalysis of the main methods of experimental elaboration of uncertainties associated with the estimation ofadsorption on micromodels is carried out in this article. As part of this work, the following studies werecarried out: • review of existing research methods and measurement of adsorption parameter; • analysis of relevant uncertainties (adsorption, core, model) and methods for their reduction; • carrying out subtle approaches in the study of adsorption on core samples using a filtration unitand measuring the polymer concentration by spectrophotometry; • reproduction of the performed experiments on the core on the scale of the micromodel. The main problems, which are reflected in detail in the course of the experiments, are the complexityof measuring the concentration spectra in the presence of the hydrocarbon phase. This problem was solvedby extracting core samples followed by pumping 4 pore volumes of polymer solution of hydrolyzedpolyacrylamide Flopaam 3630S. The main results of the experiments made it possible to clarify the value of dynamic adsorption in therange of permeabilities 450 - 1100 mD for the PK1-3 layers of the East-Messoyakhskoye field. Thus, it wasfound that the average adsorption value is 338 μg / kg of rock. The results of filtration experiments weremodeled in a commercial hydrodynamic simulator, which will allow in the future to assess the effectivenessof polymer flooding for a geological object of field development, to assess polymer losses during itsfiltration, and to clarify the economic risks associated with the project.