Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4- ones: Synthetic and biological studies

Alexander G. Majouga, Anna V. Udina, Elena K. Beloglazkina, Dmitrii A. Skvortsov, Maria I. Zvereva, Olga A. Dontsova, Nikolay V. Zyk, Nikolay S. Zefirov

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

An efficient method for the liquid-phase synthesis of 3,5-disubstituted thiohydantoins has been developed. This new class of substituted thiohydantoins was tested as DNA fluorescence probes. Anthracene-substituted thiohydantoin undergoes a change in fluorescence in the presence of DNA.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalTetrahedron Letters
Volume53
Issue number1
DOIs
Publication statusPublished - 4 Jan 2012
Externally publishedYes

Keywords

  • DNA probes
  • Fluorescence
  • Thiohydantoin

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