New derivatives of azobenzene for the directed modification of proteins

Le Tkhi Khien, B. Shirling, A. I. Riazanova, T. S. Zatsepin, E. M. Volkov, E. A. Kubareva, T. I. Velichko, A. Pingoud, T. S. Oretskaia

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Derivatives of azobenzene which contained a maleimide group in one of the benzene rings (for binding to a protein cysteine residue) and maleimide, hydroxyl, or carboxyl substitutes in another benzene ring were synthesized. The reactivity of these compounds towards a cysteine residue of a protein and their optical properties in a free state and after their attachment to the mutant forms of the SsoII restriction endonuclease were studied.

Original languageEnglish
Pages (from-to)610-617
Number of pages8
JournalBioorganicheskaia khimiia
Volume35
Issue number5
Publication statusPublished - 2009
Externally publishedYes

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