Nanoengineered polymer capsules: Tools for detection, controlled delivery, and site-specific manipulation

Gleb B. Sukhorukov, Audrey L. Rogach, Bernd Zebli, Tim Liedl, Andre G. Skirtach, Karen Köhler, Alexei A. Antipov, Nikolai Gaponik, Andrei S. Susha, Mathias Winterhalter, Wolfgang J. Parak

Research output: Contribution to journalArticlepeer-review

267 Citations (Scopus)

Abstract

The aim of nanobiotechnology is the discovery of new drug and their delivery systems, including building up of multifunctional capsules as intelligent drug carriers: once injected somewhere into blood stream the capsules would find their target, is discussed. The combination of physical, chemical, and biological approaches for designing the capsule properties is necessary to develop the capsule technology towards biological applications. It is suggested that the development of multifunctional carrier system will design surfaces and interior composition as delivery systems with (remote) stimuli-controlled release will have a strong impact on biotechnology. With multifunctionasl capsules, direction and control of the uptake of drugs by pathological cells with different methods is possible.

Original languageEnglish
Pages (from-to)194-200
Number of pages7
JournalSmall
Volume1
Issue number2
DOIs
Publication statusPublished - Feb 2005
Externally publishedYes

Keywords

  • Biomaterials
  • Drug delivery
  • Microcapsules
  • Polyelectrolytes
  • Quantum dots

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