Mutations in mitochondrial DNA and approaches for their correction

M. V. Patrushev, P. A. Kamenski, I. O. Mazunin

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Apart from the nucleus, the mitochondrion is the only organelle of an animal cell that contains its own genome. Mitochondrial DNA is much less in size than the nuclear one and codes for only several dozens of biological macromolecules. Nevertheless, mutations in mitochondrial genes often result in the occurrence of serious hereditary neuromuscular diseases. New mitochondrial DNA mutations and their relations to clinical symptoms are continuously reported in the scientific literature. In this review, we summarize existing data about such mutations, and also about contemporary gene therapy approaches that have been developed for their suppression.

Original languageEnglish
Pages (from-to)1151-1160
Number of pages10
JournalBiochemistry (Moscow)
Issue number11
Publication statusPublished - Nov 2014
Externally publishedYes


  • Gene therapy
  • Mitochondrial diseases
  • Mitochondrial DNA
  • Mitochondrial genome
  • Mutations


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