Multifunctional polyelectrolyte microcapsules as a contrast agent for photoacoustic imaging in blood

Alexey M. Yashchenok, Jithin Jose, Philippe Trochet, Gleb B. Sukhorukov, Dmitry A. Gorin

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The polyelectrolyte microcapsules that can be accurate either visualized in biological media or in tissue would enhance their further in vivo application both as a carrier of active payloads and as a specific sensor. The immobilization of active species, for instance fluorescent dyes, quantum dots, metal nanoparticles, in polymeric shell enables visualization of capsules by optical imaging techniques in aqueous solution. However, for visualization of capsules in complex media an instrument with high contrast modality requires. Herein, we show for the first time photoacoustic imaging (PAI) of multifunctional microcapsules in water and in blood. The microcapsules exhibit greater photoacoustic intensity compare to microparticles with the same composition of polymeric shell presumably their higher thermal expansion. Photoacoustic intensity form microcapsules dispersed in blood displays an enhancement (2-fold) of signal compare to blood. Photoacoustic imaging of microcapsules might contribute to non-invasive carrier visualization and further their in vivo distribution.

Original languageEnglish
Pages (from-to)792-799
Number of pages8
JournalJournal of Biophotonics
Volume9
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016
Externally publishedYes

Keywords

  • blood
  • gold nanoparticles
  • photoacoustic imaging
  • polyelectrolyte microcapsules

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