Molecular nature of breakdown of the folic acid under hydrothermal treatment: a combined experimental and DFT study

Anna M. Abramova, Alina A. Kokorina, Olga A. Sindeeva, Franck Jolibois, Pascal Puech, Gleb B. Sukhorukov, Irina Y. Goryacheva, Andrei V. Sapelkin

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Using a combination of experimental Raman, FTIR, UV–VIS absorption and emission data, together with the corresponding DFT calculations we propose the mechanism of modification of the folic acid specifically under the hydrothermal treatment at 200 °C. We established that folic acid breaks down into fragments while the pteridine moiety remains intact likely evolving into 6-formylpterin with the latter responsible for the increase in fluorescence emission at 450 nm. The results suggest that hydrothermal approach can be used for production of other purpose-engineered fluorophores.

Original languageEnglish
Article number19668
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 2020
Externally publishedYes

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