Modus operandi of the bacterial RNA polymerase containing the σ54 promoter-specificity factor

Sivaramesh Wigneshweraraj, Daniel Bose, Patricia C. Burrows, Nicolas Joly, Jörg Schumacher, Mathieu Rappas, Tillmann Pape, Xiaodong Zhang, Peter Stockley, Konstantin Severinov, Martin Buck

Research output: Contribution to journalShort surveypeer-review

95 Citations (Scopus)

Abstract

Bacterial sigma (σ) factors confer gene specificity upon the RNA polymerase, the central enzyme that catalyses gene transcription. The binding of the alternative σ factor σ54 confers upon the RNA polymerase special functional and regulatory properties, making it suited for control of several major adaptive responses. Here, we summarize our current understanding of the interactions the σ54 factor makes with the bacterial transcription machinery.

Original languageEnglish
Pages (from-to)538-546
Number of pages9
JournalMolecular Microbiology
Volume68
Issue number3
DOIs
Publication statusPublished - May 2008
Externally publishedYes

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