Modification of polyelectrolyte microcapsules into a container for the low molecular weight compounds

O. A. Goryacheva, H. Gao, G. B. Sukhorukov

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Polyelectrolyte microcapsules are one of the most successful developments in the direction of target drug delivery. Nevertheless, to encapsulate low molecular weight compounds and to deliver the targeted drugs it is necessary to modify the surface of the microcapsules. Silica nanostructures obtained as result of hydrolysis of (3-Aminopropyl)- triethoxysilane (APTES) were used for the modification of the microcapsules. This material shows no toxic effect on cells and is capable of biodegradation. Amino-groups in the structure of APTES make it possible for further direct bioconjugation.

Original languageEnglish
Title of host publicationSaratov Fall Meeting 2017
Subtitle of host publicationOptical Technologies in Biophysics and Medicine XIX
EditorsValery V. Tuchin, Elina A. Genina, Irina Yu. Goryacheva, Elina A. Genina, Irina Yu. Goryacheva
PublisherSPIE
ISBN (Electronic)9781510620018
DOIs
Publication statusPublished - 2018
Externally publishedYes
EventSaratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX - Saratov, Russian Federation
Duration: 26 Sep 201730 Sep 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10716
ISSN (Print)1605-7422

Conference

ConferenceSaratov Fall Meeting 2017: Optical Technologies in Biophysics and Medicine XIX
Country/TerritoryRussian Federation
CitySaratov
Period26/09/1730/09/17

Keywords

  • drug delivery
  • microcapsules
  • permeability
  • silica coating

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