Modeling and simulation of tissue spheroids fusion based on the function representation approach

Catherine Pakhomova, Alexander Pasko, Iskander Akhatov

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Mathematical modeling for 3D bioprinting allows us to avoid widespread errors and also time and financial losses. It is necessary for such critical processes as tissue spheroids fusion and diffusion of nutrients in them. The reason is that tissue spheroids fusion is the base of the 3D bioprinting technology. In this work, we propose an approach for tissue spheroids fusion modeling considering a need to compromise between fidelity of the geometric form and viability of the whole bioconstruct.

Original languageEnglish
Title of host publicationApplied Materials Engineering Research
EditorsJong Wan Hu
PublisherTrans Tech Publications Ltd
Pages119-123
Number of pages5
ISBN (Print)9783035718652
DOIs
Publication statusPublished - 2021
Event4th International Conference on Material Engineering Research, ICMER 2021, and the 6th International Conference on Applied Engineering, Materials and Mechanics, ICAEMM 2021 - Incheon, Korea, Republic of
Duration: 14 May 202116 May 2021

Publication series

NameMaterials Science Forum
Volume1046 MSF
ISSN (Print)0255-5476
ISSN (Electronic)1662-9752

Conference

Conference4th International Conference on Material Engineering Research, ICMER 2021, and the 6th International Conference on Applied Engineering, Materials and Mechanics, ICAEMM 2021
Country/TerritoryKorea, Republic of
CityIncheon
Period14/05/2116/05/21

Keywords

  • 3D bioprinting
  • Cellular necrosis
  • Diffusion-reaction dependence
  • Function Representation (FRep)
  • Geometric modeling
  • Mathematical modeling
  • Neumann boundary conditions
  • R-functions
  • Robotic biofabrication
  • Tissue spheroids
  • Visualization

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