MMSSC chemotaxis near porous surface of biocompatible NiTi scaffolds synthesized by Selective Laser Sintering (SLS)

Igor V. Shishkovsky, Stanislav E. Volchkov, Olga V. Tumina

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

Multipotential mesenchymal stromal stem cells (MMSSC) are an excellent model for testing of the toxicity and biocompatibility of natural-tissue- engineering scaffolds (extracellular matrix). Such studies allow prediction of the behavior of implanted materials in the human. In the present work, testing of a three-dimensional prototype of a smart material - nitinol (the intermetallic phase NiTi) - to evaluate chemotaxis and biocompatibility was conducted. Porous samples were synthesized by the selective laser sintering (SLS) method, establishing different surface conditions in the samples. The surface microstructure and roughness were observed by scanning electron microscopy (SEM) and optical microscopy. The results revealed the clear influence of the surface roughness on stem cell proliferation, morphology, and adhesion. The NiTi samples were well tolerated by the cells but the number of focal contacts decreased with increasing porosity. The proliferation speed was 0.694 doubling/day in the control group and 0.532 doubling/day for the NiTi group. Whereas the control group showed immature and actively divided stem cells, cell growth to enormous sizes (i.e., rapid aging) and a fall in fission activity in the proximity of an external irritant (viz., the NiTi scaffold) was observed.

Original languageEnglish
Title of host publicationBiomaterials for Tissue Regeneration
Pages86-91
Number of pages6
DOIs
Publication statusPublished - 2012
Externally publishedYes
Event2011 MRS Fall Meeting - Boston, MA, United States
Duration: 28 Nov 20112 Dec 2011

Publication series

NameMaterials Research Society Symposium Proceedings
Volume1417
ISSN (Print)0272-9172

Conference

Conference2011 MRS Fall Meeting
Country/TerritoryUnited States
CityBoston, MA
Period28/11/112/12/11

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