Mining for Small Translated ORFs

Anastasia Chugunova, Tsimafei Navalayeu, Olga Dontsova, Petr Sergiev

    Research output: Contribution to journalReview articlepeer-review

    25 Citations (Scopus)

    Abstract

    Peptides encoded by short open reading frames (sORFs) are usually defined as peptides ≤100 aa long. Usually sORFs were ignored by automatic genome annotation programs due to the high probability of false discovery. However, improved computational tools along with a high-throughput RIBO-seq approach identified a myriad of translated sORFs. Their importance becomes evident as we are gaining experimental validation of their diverse cellular functions. This Review examines various computational and experimental approaches of sORFs identification as well as provides the summary of our current knowledge of their functional roles in cells.

    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalUnknown Journal
    Volume17
    Issue number1
    DOIs
    Publication statusPublished - 5 Jan 2018

    Keywords

    • coding potential
    • genome annotation
    • lncRNA
    • peptide
    • RIBO-seq
    • ribosome profiling
    • small ORF
    • small peptide
    • translation
    • uORF

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