Microscopy Image Restoration with Deep Wiener-Kolmogorov Filters

Valeriya Pronina, Filippos Kokkinos, Dmitry V. Dylov, Stamatios Lefkimmiatis

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

6 Citations (Scopus)


Microscopy is a powerful visualization tool in biology, enabling the study of cells, tissues, and the fundamental biological processes; yet, the observed images typically suffer from blur and background noise. In this work, we propose a unifying framework of algorithms for Gaussian image deblurring and denoising. These algorithms are based on deep learning techniques for the design of learnable regularizers integrated into the Wiener-Kolmogorov filter. Our extensive experimentation line showcases that the proposed approach achieves a superior quality of image reconstruction and surpasses the solutions that rely either on deep learning or on optimization schemes alone. Augmented with the variance stabilizing transformation, the proposed reconstruction pipeline can also be successfully applied to the problem of Poisson image deblurring, surpassing the state-of-the-art methods. Moreover, several variants of the proposed framework demonstrate competitive performance at low computational complexity, which is of high importance for real-time imaging applications.

Original languageEnglish
Title of host publicationComputer Vision – ECCV 2020 - 16th European Conference 2020, Proceedings
EditorsAndrea Vedaldi, Horst Bischof, Thomas Brox, Jan-Michael Frahm
PublisherSpringer Science and Business Media Deutschland GmbH
Number of pages17
ISBN (Print)9783030585648
Publication statusPublished - 2020
Event16th European Conference on Computer Vision, ECCV 2020 - Glasgow, United Kingdom
Duration: 23 Aug 202028 Aug 2020

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12365 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference16th European Conference on Computer Vision, ECCV 2020
Country/TerritoryUnited Kingdom


  • Deblurring
  • Denoising
  • Learnable regularizers
  • Microscopy deblurring
  • Wiener filter


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