Microscopic and macroscopic spectral peculiarities of cutaneous tumours

Ekaterina Borisova, Tsanislava Genova, Petranka Troyanova, Ivan Terziev, Valery Zakharov, Ivan Bratchenko, Maria Lomova, Dmitry Gorin, Latchezar Avramov

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Autofluorescence spectral and confocal microscopic measurements were made on different cutaneous neoplastic lesions, namely basal cell carcinoma, squamous cell carcinoma, malignant melanoma, and their dysplastic forms-keratoacantoma, dysplastic nevi and benign lesions related-basal cell papiloma, seboreic keratosa and compound nevi using excitation at 405 nm. Spectroscopic investigations were made on in vivo and ex vivo tissue samples, and confocal microscopy investigations were made on ex vivo and eosin-haematoxilin stained thin slices of the tumours detected. Correlation between the spectral data received and the microscopic features observed was found, related to the morphological and biochemical alterations during neoplasia growth. Specific spectral features observed in each type of lesion investigated on micro and macro level would be presented and discussed.

Original languageEnglish
Title of host publicationBiophotonics - Riga 2017
EditorsJanis Spigulis
PublisherSPIE
ISBN (Electronic)9781510616769
DOIs
Publication statusPublished - 2017
Externally publishedYes
Event2nd International Conference on Biophotonics-Riga 2017, BPR 2017 - Riga, Latvia
Duration: 27 Aug 201729 Aug 2017

Publication series

NameProceedings of SPIE

Conference

Conference2nd International Conference on Biophotonics-Riga 2017, BPR 2017
Country/TerritoryLatvia
CityRiga
Period27/08/1729/08/17

Keywords

  • Autofluorescence (AF) spectroscopy
  • Basal cell carcinoma (BCC)
  • Confocal fluorescent microscopy (CFM)
  • Malignant melanoma (MM)
  • Optical biopsy
  • Squmanous cell carcinoma (SCC)

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