Methods of horizontal gene transfer determination using phylogenetic data

Vassily A. Lyubetsky, Vladimir V. V'yugin

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A new approach for comparative analysis of multiple trees reconstructed for representative protein families is proposed. This approach is based on the hypothesis of gene duplication, gene loss and horizontal gene transfer and makes use of stochastic methods and optimization. We present a species tree of 40 prokaryotic organisms obtained by our algorithm on the basis of 132 clusters of orthologous groups of proteins (COGs) from the GenBank of the National Center for Biotechnology Information (USA). We also present a computer technology intended to determine horizontally transferred genes. Some application results of the technology, based on comparative analysis of protein and species trees, are given.

Original languageEnglish
Pages (from-to)17-31
Number of pages15
JournalIn Silico Biology
Volume3
Issue number1-2
Publication statusPublished - 2003
Externally publishedYes

Keywords

  • Consensus trees
  • Evolution
  • Horizontal gene transfer
  • Mathematical models of evolution
  • Phylogenetic trees
  • Stochastic optimization

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