Magnetic resonance imaging of endothelial cells with vectorized iron oxide nanoparticles

M. A. Abakumov, A. E. Goldt, M. Sokolsky-Papkov, Y. A. Zorkina, V. P. Baklaushev, E. A. Goodilin, A. V. Kabanov, V. P. Chekhonin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We propose a method for obtaining superparamagnetic nanoparticles based on iron oxide and their water suspensions. The structure and size of nanoparticles were confi rmed by transmission electron microscopy, dynamic light scattering, and X-ray diffraction analysis. The nanoparticles also contained a fl uorescent dye Dil C18. Cytotoxicity of obtained aqueous suspension was studied by MTT assay; low toxicity of nanoparticles was demonstrated. High T2-relaxivity of nanoparticles allows using them as a contrast agent for MRI. After incubation of cerebellar sections with nanoparticles vectorized with antibodies to antigen AMVB1, specifi c visualization of blood vessels was detected.

Original languageEnglish
Pages (from-to)726-730
Number of pages5
JournalBulletin of Experimental Biology and Medicine
Volume151
Issue number6
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Keywords

  • MRI contrast
  • superparamagnetic nanoparticles
  • vector delivery

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