Low-molecular-weight post-translationally modified microcins

Konstantin Severinov, Ekaterina Semenova, Alexey Kazakov, Teymur Kazakov, Mikhail S. Gelfand

Research output: Contribution to journalShort surveypeer-review

108 Citations (Scopus)


Microcins are a class of ribosomally synthesized antibacterial peptides produced by Enterobacteriaceae and active against closely related bacterial species. While some microcins are active as unmodified peptides, others are heavily modified by dedicated maturation enzymes. Low-molecular-weight microcins from the post-translationally modified group target essential molecular machines inside the cells. In this review, available structural and functional data about three such microcins - microcin J25, microcin B17 and microcin C7-C51 - are discussed. While all three low-molecular-weight post-translationally modified microcins are produced by Escherichia coli, inferences based on sequence and structural similarities with peptides encoded or produced by phylogenetically diverse bacteria are made whenever possible to put these compounds into a larger perspective.

Original languageEnglish
Pages (from-to)1380-1394
Number of pages15
JournalMolecular Microbiology
Issue number6
Publication statusPublished - Sep 2007
Externally publishedYes


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