Low-molecular-weight inhibitors of bacterial DNA-dependent RNA polymerase

S. D. Zorov, J. V. Yuzenkova, K. V. Severinov

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

The review considers low-molecular-weight inhibitors of bacterial RNA polymerase (RNAP), including classical agents and new compounds lacking clinical application as antibiotics thus far. Recent progress in the field is due to structural studies. Structural information, together with biochemical data, sheds light on the mechanism of action of the inhibitors, such as rifampicin, sorangicin, tagetitoxin, streptolygidin, and microcin J25. In turn, the mechanisms of RNAP inhibition provide for a better understanding of the transcription mechanism, as well as the structure and function of RNAP.

Original languageEnglish
Pages (from-to)875-884
Number of pages10
JournalMolecular Biology
Volume40
Issue number6
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Keywords

  • CBR703
  • CBR9379
  • CBR9393
  • Daunomycin
  • Inhibitors of bacterial RNA polymerase
  • Lipiarmycin
  • Marcellomycin
  • Microcin J25
  • Rifabutin
  • Rifampicin
  • Rifamycins
  • Rifapentin
  • Sorangicin
  • Streptolydigin
  • Tagetitoxin

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