Low conservation of alternative splicing patterns in the human and mouse genomes

Ramil N. Nurtdinov, Irena I. Artamonova, Andrei A. Mironov, Mikhail S. Gelfand

Research output: Contribution to journalArticlepeer-review

114 Citations (Scopus)

Abstract

Alternative splicing has recently emerged as a major mechanism of generating protein diversity in higher eukaryotes. We compared alternative splicing isoforms of 166 pairs of orthologous human and mouse genes. As the mRNA and EST libraries of human and mouse are not complete and thus cannot be compared directly, we instead analyzed whether known cassette exons or alternative splicing sites from one genome are conserved in the other genome. We demonstrate that about half of the analyzed genes have species-specific isoforms, and about a quarter of elementary alternatives are not conserved between the human and mouse genomes. The detailed results of this study are available at www.ig-msk.ru:8005/HMG_paper.

Original languageEnglish
Pages (from-to)1313-1320
Number of pages8
JournalHuman Molecular Genetics
Volume12
Issue number11
DOIs
Publication statusPublished - 1 Jun 2003
Externally publishedYes

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