Localization of the endothelin-B receptor using a transgenic approach

Adele Gordon, David Webb, Myung Shin, Yuri Kotelevtsev

Research output: Contribution to journalArticlepeer-review


The use of reporter genes such as β-galactosidase and green fluorescent protein is a powerful molecular tool for the visualization of in-vivo gene expression. In this paper, we describe the generation of mice that possess a β-galactosidase reporter gene introduced into the endothelin-B receptor locus by homologous recombination in embryonic stem cells. These mice express β-galactosidase wherever endothelin-B is expressed and therefore provide a precise in-vivo localization profile of endothelin-B expression.

Original languageEnglish
Pages (from-to)S144-S146
JournalJournal of Cardiovascular Pharmacology
Issue numberSUPPL. 1
Publication statusPublished - Nov 2004
Externally publishedYes


  • β-galactosidase
  • Endothelin-B (ET)
  • LacZ
  • Localization
  • Mice


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