The use of reporter genes such as β-galactosidase and green fluorescent protein is a powerful molecular tool for the visualization of in-vivo gene expression. In this paper, we describe the generation of mice that possess a β-galactosidase reporter gene introduced into the endothelin-B receptor locus by homologous recombination in embryonic stem cells. These mice express β-galactosidase wherever endothelin-B is expressed and therefore provide a precise in-vivo localization profile of endothelin-B expression.
|Journal||Journal of Cardiovascular Pharmacology|
|Issue number||SUPPL. 1|
|Publication status||Published - Nov 2004|
- Endothelin-B (ET)