Lipidomics: New perspectives on search for markers of neoplasia

Maria Evgenievna Nekrasova, Niso Mirzoevna Nazarova, Nataliia Leonidovna Starodubtseva, Vitaliy Viktorovich Chagovets, Alexey Sergeevich Kononikhin, Vladimir Evgenievich Frankevich, Vera Nikolaevna Prilepskaya

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Objective. To conduct a systematic analysis of the data available in the current literature on the role of lipids in carcinogenesis and the importance of lipid markers in the diagnosis of HPV-associated cervical diseases and to provide perspectives on the lipidomic analysis of cervical tissue in predicting the course of cervical neoplastic processes. Material and methods. The review includes data from 46 foreign articles published in the past 5 years and found in Pubmed and Scopus on this topic. Results. The paper describes a number of lipid markers of tissues in different organs for the early diagnosis of precancerous and cancerous lesions, by estimating the degree of diagnostic significance. Conclusion. It is necessary to conduct further studies aimed at identifying specific lipid markers for the early diagnosis and prognosis of human papillomavirus-associated cervical diseases.

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalAkusherstvo i Ginekologiya (Russian Federation)
Issue number3
DOIs
Publication statusPublished - 2017
Externally publishedYes

Keywords

  • Cervical cancer
  • Cervical intraepithelial neoplasia
  • Human papillomavirus
  • Lipidomics
  • Mass-spectrometry
  • Phospholipids

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