LIPID markers of cervical epithelium neoplastic transformation in HPV-associated diseases

Maria Evgenievna Nekrasova, Vitaliy Viktorovich Chagovets, Nataliia Leonidovna Starodubtseva, Alexey Sergeevich Kononikhin, Dinara Failevna Salimova, Alisa Olegovna Tokareva, Vadim Vladimirovich Lagutin, Vladimir Aleksandrovich Naumov, Niso Mirzoevna Nazarova, Vladimir Evgenievich Frankevich, Gennadiy Tikhonovich Sukhikh

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Objective. To discover peculiarities of the lipid composition of neoplastically transformed and adjacent cervical epithelium with HPV-associated diseases. Material and methods. The study included 41 patients with neoplastic transformations of the cervical epithelium, caused by human papillomavirus, who applied to outpatient department of Federal State Budget Institution “National Medical Research Center for Obstetrics, Gynecology and Perinatology” Ministry Of Healthcare of the Russian Federation. biopsy of the cervix uteri (strictly according to the indications for biopsy) with subsequent histological examination of the biopsy specimens and analysis of their lipid composition were performed in all women, included in the study. Qualitative and quantitative assessment of biopsy samples lipid extracts was performed by mass spectrometry with electrospray ionization. Lipids of five classes were identified: phosphatidylcholines, phosphatidylethanolamines, sphingomyelins, di – and triglycerides. The obtained experimental data were analyzed using the multivariate OPLS-DA method. Results. A statistically meaningful change in the levels of lipids, such as phosphatidylcholines (PC 32:0, PC 34:1, PC 36:4, PC 34:0, PC 38:4), phosphatidylethanolamines (PE O-46:0, LPE 46:0, PE O-48:0, LPE 48:0, PE O-46:1) and sphingomyelins (SM 34:0, SM 42:2) was identified in cervical tissues with neoplastic transformation, caused by human papillomavirus. Conclusion. This study revealed significant changes in the content of several glycerophospholipids and sphingolipids in neoplastically transformed tissues of the cervix uteri compared to adjacent normal tissues. Found lipids can be used as a part of the prognostic panel to predict the course of cervical neoplasias in the direction of regress or malignancy.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalAkusherstvo i Ginekologiya (Russian Federation)
Issue number4
Publication statusPublished - 2018
Externally publishedYes


  • Biomarkers
  • Cervical cancer
  • Cervical intraepithelial neoplasia
  • Human papillomavirus
  • Lipids
  • Mass spectrometry
  • Microenvironment
  • Phosphatidylcholine
  • Sphingomyelin


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