LIF, a novel STAT5-regulated gene, is aberrantly expressed in myeloproliferative neoplasms

Elisa M. Salas, María J. García-Barchino, Sara Labiano, Mikhail Shugay, Manuel Pérez-Encinas, Celsa Quinteiro, Marina García-Delgado, José L. Vizmanos, Francisco J. Novo

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A search for genes potentially regulated by STAT5 identified leukemia inhibitory factor (LIF) as a good candidate. Using various experimental approaches, we have validated LIF as a direct transcriptional target of STAT5 in myeloid cell lines: STAT5 binds to LIF promoter, and LIF expression is increased after activation of the JAK2/STAT5 pathway. We also found that LIF expression is significantly increased in patients with chronic myeloproliferative neoplasms with and without activating mutations of the pathway, indicating that LIF might play an important role in STAT5-mediated oncogenesis.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalGenes and Cancer
Volume2
Issue number5
DOIs
Publication statusPublished - May 2011
Externally publishedYes

Keywords

  • LIF
  • myeloproliferative neoplasms
  • STAT5

Fingerprint

Dive into the research topics of 'LIF, a novel STAT5-regulated gene, is aberrantly expressed in myeloproliferative neoplasms'. Together they form a unique fingerprint.

Cite this