Layer-by-layer nanoassembly of polyion and enzymes for production of micropatterns and nanoshells

Y. Lvov, T. Cui, F. Hua, A. Patel, A. Antipov, A. Cordeiro, M. Prevot, G. Sukhorukov, R. Besser

Research output: Contribution to journalConference articlepeer-review

2 Citations (Scopus)


A layer-by-layer nanoassembly (LbL) allows production of ultrathin films with a precision of 1-2 nm and needed composition across the multilayer. It was used in combination with traditional lithography to develop micropatterns in ordered nanoparticle multilayers. A selective nanoparticle film growth was also demonstrated for microchannel silicon chips. Microfluidic properties of nanoorganized polymer microcapsules were studied with the microchannel device. Nanoorganized microcapsules production: A LbL-assembly of 20-nm thick poly(styrenesulfonate) / poly(allylamine) shell on microtemplates and loading such hollow polyion shells with enzymes allowed fabrication of catalytic "bioreactors," as it was demonstrated for glucose oxidase, hemoglobin, and myoglobin ensembles.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2003
Externally publishedYes
EventSmart Structures and Materials 2003: Smart Electronics, MEMS, BioMEMS, and Nanotechnology - San Diego, CA, United States
Duration: 3 Mar 20035 Mar 2003


  • 2D micropatterning
  • Enzymes
  • Layer-by-layer assembly
  • Microshells
  • Nanoorganized multilayers


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