Layer-by-layer coating of degradable microgels for pulsed drug delivery

B. G. De Geest, C. Déjugnat, E. Verhoeven, G. B. Sukhorukov, A. M. Jonas, J. Plain, J. Demeester, S. C. De Smedt

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

Recently, we reported on "self-rupturing" microcapsules which consist of a biodegradable dextran-based microgel surrounded by a polyelectrolyte membrane. Degradation of the microgel increases the swelling pressure in the microcapsules which, when sufficiently high, ruptures the surrounding polyelectrolyte membrane. The membrane surrounding the microgels is deposited using the layer-by-layer (LbL) technique, which is based on the alternate adsorption of oppositely charged polyelectrolytes onto a charged substrate. In this paper, we characterize with confocal microscopy, electrophoretic mobility, scanning electron microscopy and atomic force microscopy in detail the deposition and the properties of the LbL coatings on the dextran microgels. We show that by fine-tuning the properties of both the microgel core and the LbL membrane the swelling pressure which is evoked by the degradation of the microgel is indeed able to rupture the surrounding LbL membrane. Further, we show that the application of an LbL coating on the surface of the microgels dramatically lowers the burst release from the microcapsules and results in massive release at the time the microcapsules rupture.

Original languageEnglish
Pages (from-to)159-169
Number of pages11
JournalJournal of Controlled Release
Volume116
Issue number2 SPEC. ISS.
DOIs
Publication statusPublished - 28 Nov 2006
Externally publishedYes

Keywords

  • Capsules
  • Layer-by-layer
  • Microgels
  • Polyelectrolytes
  • Pulsed release

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